Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetMovement of ribosomes along the mRNA

Target IC₅₀: ≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity

General description

Principle alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC₅₀ ≤1 µM.

Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC₅₀ ≤1 µM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kong, H.S., et al. 2010. Mol. Pharmacol.in press.Khan, M.A. 1995. Prog. Neurobiol.46, 541.Kokuho, T., et al. 1995. Immunobiology193, 42.Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett.93, 157.Burhans, W.C., et al. 1991. EMBO J. 10, 4351.Filley, E.A., and Rook, G.A. 1991. Infect. Immun.59, 2567.Landis, R.C., et al. 1991. J. Immunol.146, 128.Schweighoffer, T., et al. 1991. Histochemistry96, 93.

Packaging

250 mg in Alu drum

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Highly Toxic (H)